Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution.
Marianna BeghiniStephanie BrandtIngrid KörberKatja KohlsdorfHeike VollbachBelinda LennerzChristian DenzerShlomit ShalitinFerruccio SantiniWerner F BlumJulia von SchnurbeinMartin WabitschPublished in: International journal of obesity (2005) (2021)
These results in CLD patients are contrary to observations in children with idiopathic obesity who typically have above-mean IGF1 levels that decrease with weight loss, and therefore suggest that leptin increases IGF1 levels and promotes linear growth.
Keyphrases
- weight loss
- end stage renal disease
- young adults
- pi k akt
- binding protein
- bariatric surgery
- newly diagnosed
- chronic kidney disease
- ejection fraction
- metabolic syndrome
- insulin resistance
- growth hormone
- roux en y gastric bypass
- prognostic factors
- peritoneal dialysis
- gastric bypass
- body mass index
- adipose tissue
- patient reported outcomes
- signaling pathway
- patient reported
- glycemic control