Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication.

Hongliang LiuChao LiangHong DuanXiaobin ZhangXiangpeng WangShuqi XiaoEn-Min Zhou

Published in: Biotechnology letters (2016)

Intracellularly expressed Nb41 and Nb43 potently suppressed PRRSV replication in MARC-145 cells. Nanobodies hold great potential for development as novel antiviral treatments for PRRSV infection.

Keyphrases

induced apoptosis
cell cycle arrest
amino acid
signaling pathway
risk assessment
cell death
human health
binding protein
climate change