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Gene expression in peripheral blood in treatment-free major depression.

Alfredo B Cuellar-BarbozaJorge A Sanchez-RuizIram P Rodriguez-SanchezSarai GonzálezGeovana CalvoJosé LugoAntonio Costilla-EsquivelLaura E MartínezMarisol Ibarra-Ramirez
Published in: Acta neuropsychiatrica (2020)
GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.
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