NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model.

Sang Hoon LeeMi Hwa ShinAh Young LeemSu Hwan LeeKyung Soo ChungYoung Sam KimMoo Suk Park

Published in: Respiratory research (2022)

In the VILI model with high tidal volume, NOX4 KO, EphA2 KO or monoclonal antibodies attenuated the VILI. NOX4 and EphA2 levels were significantly higher in patients with pneumonia and especially in mechanical ventilated in the ICU. Inhibition of Nox4 is a potential therapeutic target for the prevention and reduction of VILI.

Keyphrases

mouse model
intensive care unit
reactive oxygen species
acute respiratory distress syndrome
mechanical ventilation
high glucose
respiratory failure
oxidative stress
human health
risk assessment
community acquired pneumonia
stress induced