Prediction of imminent fracture risk in Canadian women and men aged 45 years or older: external validation of the Fracture Risk Evaluation Model (FREM).
Sören MöllerMichael Kriegbaum SkjødtLin YanBo AbrahamsenLisa M LixEugene V McCloskeyHelena JohanssonNicholas C W HarveyJohn A KanisKatrine Hass RubinWilliam D LesliePublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)
In conclusion, the FREM algorithm shows significant fracture risk stratification when applied to an independent clinical population from Manitoba, Canada. Overall calibration for MOF prediction was good, but hip fracture risk was systematically overestimated indicating the need for recalibration.