Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB-PET Threshold.
Rola IsmailPeter ParboKim V HansenJeppe L SchaldemoseRikke B DalbyAnna TietzePernille L KjeldsenSanne Hage la CourPer QvistHanne GottrupSimon F EskildsenDavid J BrooksPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2019)
Use of a PiB SUVR threshold of >1.5 for raised amyloid missed 14.3% of MCI cases who likely had Thal stage 1 or 2 pathology and showed a progressive amyloid increase over 2 years. Lowering the threshold for abnormality to 1.3 abolished all false negatives but resulted in 75% of HCs being falsely diagnosed as raised amyloid subjects.