Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study).

Sine KnorrAnne SkakkebækJesper JustEmma B JohannsenChristian TrolleSøren VangZuzana LohseBirgitte BytoftPeter DammKurt HøjlundDorte M JensenClaus H Gravholt

Published in: BMC medicine (2022)

These findings suggest the possibility for intrauterine exposure to maternal T1DM to impact later in life methylation and gene expression in the offspring, a profile that may be linked to the increased risk of vascular and metabolic disease later in life.

Keyphrases

gene expression
dna methylation
high fat diet
pregnancy outcomes
polycystic ovary syndrome
genome wide
type diabetes
low birth weight
adipose tissue
metabolic syndrome
preterm infants
breast cancer risk