Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression.

Thomas H JonkmanKoen F DekkersRoderick C SliekerCrystal D GrantM Arfan IkramMarleen M J van GreevenbroekLude FrankeJan H VeldinkDorret I BoomsmaP Eline SlagboomB I O S ConsortiumBastiaan T Heijmans

Published in: Genome biology (2022)

The ability of epigenetic clocks to predict chronological age involves their ability to detect changes in proportions of naive and activated immune blood cells, an established feature of immuno-senescence. This finding may contribute to the interpretation of associations between clock-derived measures and age-related health outcomes.

Keyphrases

nk cells
dna methylation
induced apoptosis
gene expression
genome wide
cell cycle arrest
machine learning
dna damage
deep learning
hiv infected
endothelial cells
single cell
cell death
signaling pathway
oxidative stress