Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential.

Kara A MoserElliott F DrábekAnkit DwivediEmily M StuckeJonathan CrabtreeAntoine DaraZalak ShahMatthew AdamsTao LiPriscila T RodriguesSergey KorenAdam M PhillippyJames B MunroAmed OuattaraBenjamin C SparklinJulie C Dunning HotoppKirsten E LykeLisa SadzewiczLuke J TallonMichele D SpringKrisada JongsakulChanthap LonDavid L SaundersMarcelo U FerreiraMyaing M NyuntMiriam K LauferMark A TravassosRobert W SauerweinShannon Takala-HarrisonClaire M FraserB Kim Lee SimStephen L HoffmanChristopher V PloweJoana C Silva

Published in: Genome medicine (2020)

These results will assist in the interpretation of vaccine efficacy of whole-organism vaccines against homologous and heterologous CHMI.

Keyphrases

plasmodium falciparum
escherichia coli
dna damage
dna repair
genome wide
risk assessment
climate change