Aldosterone Antagonism Is More Effective at Reducing Blood Pressure and Excessive Renal ENaC Activity in AngII-Infused Female Rats Than in Males.
Vadym BunchaAlena CherezovaSati AlexanderIrina L BaranovskayaKathleen A ColemanMary Cherian-ShawMichael W BrandsJennifer C SullivanPaul M O'ConnorMykola MamenkoPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
MR-ENaC axis is the primary determinant of excessive renal sodium reabsorption and an attractive antihypertensive target in female rats with AngII-hypertension, but not in males.