Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors, pannexons and Toll-like receptor 4.
Jihui ZhangJie ChenShannon C MangatChathuri Perera BaruhupolageDavid R GarrodClive RobinsonPublished in: Immunity, inflammation and disease (2018)
Our data identify for the first time that endogenously-generated prothrombin and TLR4 form a shared effector mechanism essential to intracellular ROS generation activated by a group 1 HDM allergen (itself a prothrombinase) or by ligation of viral RNA-sensing TLRs. These stimuli operate a confluent signaling pathway in which myosin motors, gating of pannexons, and ADAM 10 lead to prothrombin-dependent activation of TLR4 with a recycling activation of pannexons.
Keyphrases
- toll like receptor
- inflammatory response
- nuclear factor
- signaling pathway
- immune response
- sars cov
- binding protein
- reactive oxygen species
- allergic rhinitis
- dendritic cells
- cell death
- epithelial mesenchymal transition
- dna damage
- regulatory t cells
- nucleic acid
- health risk
- human health
- anti inflammatory
- health risk assessment
- risk assessment
- deep learning
- type iii
- drinking water