Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.

Adrian Zietara Denisha R SpiresAlexandria JuffreHannah M CostelloG Ryan CrislipLauren G DoumaVladislav LevchenkoLashodya V DissanayakeChristine A KlemensOksana NikolaienkoAron M Geurts Michelle L GumzAlexander Staruschenko

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Altogether, our findings demonstrate that loss of PER1 in Dahl SS rats causes an array of deleterious effects, including exacerbation of the development of salt-sensitive hypertension and renal damage.

Keyphrases

blood pressure
chronic obstructive pulmonary disease
oxidative stress
high resolution
high throughput
binding protein
arterial hypertension
single cell
acute respiratory distress syndrome