PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.

Fang ZhengJiamin ZhongKelie ChenYu ShiFang WangShengchao WangSong TangXiaoyu YuanZhangjin ShenSangsang TangDajing XiaYihua WuWei-Guo Lv

Published in: Journal of experimental & clinical cancer research : CR (2023)

PINK1 interacts with and phosphorylates PTEN at Serine179, resulting in the activation of AKT and the inhibition of PTEN nuclear import. PINK1 promotes ovarian cancer metastasis and chemotherapy resistance through the regulation of PTEN. These findings offer new potential therapeutic targets for ovarian cancer management.

Keyphrases

cell proliferation
pi k akt
signaling pathway
radiation therapy
risk assessment
locally advanced
protein kinase
rectal cancer
climate change
chemotherapy induced