Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling.

Yichao WuChangbiao LiAbid Ali KhanKangchen ChenRenyi SuShengjun XuYiyang SunFengqiang GaoKai WangXiaodong WangZhengxing LianShuo WangMengyuan YuXin HuFan YangShusen ZhengNasha QiuZhikun LiuXiao Xu

Published in: Journal of translational medicine (2023)

Insig2 has a protective function in liver IR by upregulating the PPP activity and remodeling glucose metabolism. The supplementary glucose 6-phosphate (G6P) salt may serve as a viable therapeutic target for alleviating hepatic IR.

Keyphrases

ischemia reperfusion injury
type diabetes
oxidative stress
high glucose
diabetic rats
genome wide
blood glucose
glycemic control
dna methylation
metabolic syndrome
blood pressure
endothelial cells
transcription factor
skeletal muscle