Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy.

Dingkang LiuHaibo RongYe ChenQun WangSijia QianYue JiWenbing YaoJun Yin Xiang-Dong Gao

Published in: British journal of pharmacology (2022)

Our results revealed a previously unrecognized pattern of reversal of drug resistance and have suggested mitochondria as a clinically relevant target for the treatment of MDR malignant tumours.

Keyphrases

cancer therapy
drug delivery
cell death
reactive oxygen species
endoplasmic reticulum
single cell
combination therapy
smoking cessation