Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.
Patricia SnarskiSergiy SukhanovTadashi YoshidaYusuke HigashiSvitlana DanchukBysani ChandrasekarDi TianVikara Rivera-LopezPatrick DelafontainePublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Macrophage IGF-1 overexpression reduced atherosclerotic burden and increased features of plaque stability, likely via a reduction in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.