Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.

Patricia SnarskiSergiy SukhanovTadashi YoshidaYusuke HigashiSvitlana DanchukBysani Chandrasekar Di TianVikara Rivera-LopezPatrick Delafontaine

Published in: Arteriosclerosis, thrombosis, and vascular biology (2021)

Macrophage IGF-1 overexpression reduced atherosclerotic burden and increased features of plaque stability, likely via a reduction in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.

Keyphrases

adipose tissue
cell proliferation
transcription factor
pi k akt
binding protein
dendritic cells
coronary artery disease
signaling pathway
cognitive decline
risk factors
high fat diet
endothelial cells
peripheral blood
immune response
insulin resistance