Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment.
Maud van DintherAstrid M HooghiemstraEsther E BronAdriaan VersteegAnna E LeeuwisTugba KalayJustine E MoonenSanne KuipersWalter H BackesJacobus F A JansenMathias J P van OschGeert-Jan BiesselsJulie StaalsRobert J van Oostenbruggenull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Impaired cerebral blood flow (CBF) at baseline is associated with faster cognitive decline in VCI and normal aging. Our results suggest that low CBF precedes and contributes to the development of vascular cognitive impairment. CBF determined by ASL might be used as a biomarker to monitor disease progression or treatment responses in VCI.