Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
Yalan LeiJin XuMingming XiaoDi WuHe XuJing YangXiaoqi MaoHaoqi PanXian-Jun YuXianjun YuPublished in: British journal of cancer (2024)
Pirfenidone may alter the pancreatic milieu and alleviate fibrosis through the regulation of tumour-stroma interactions via the TGM2/NF-kB/PDGFB signalling pathway, suggesting potential therapeutic benefits in PDAC management.