The heat shock factor HSF1 juggles protein quality control and metabolic regulation.

Published in: The Journal of cell biology (2017)

Transcriptional regulators often act as central hubs to integrate multiple nutrient and stress signals. In this issue, Qiao et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607091) demonstrate how heat shock factor 1 (HSF1) uncouples metabolic control from proteostatic regulation and unveils HSF1 as a critical transcriptional regulator of NAD+ metabolism.

Keyphrases

heat shock
quality control
heat stress
heat shock protein
transcription factor
oxidative stress
single cell
cell therapy
stem cells
amino acid
binding protein
bone marrow