Ibuprofen and postoperative bleeding in children undergoing tonsillectomy or adenotonsillectomy: a systematic review and meta-analysis of randomized clinical trials.
Alessandro SimoniniFrancesco MurgiaMarco CascellaFranco MarinangeliAlessandro VittoriMaria Grazia CalevoPublished in: Expert review of clinical pharmacology (2020)
Given the imprecision of our estimates, the quality of evidence very low/moderate and the few RCTs identified, the results of this analysis were consistent with either a benefit or a detrimental effect of the administration of ibuprofen and do not provide a definitive answer to the review question. Further studies are needed on this important topic.