Comparing Singlet Oxygen Generation of Schiff Base Substituted Novel Silicon Phthalocyanines by Sono-photochemical and Photochemical Applications.

Although the sono-photodynamic method has an effective therapeutic outcome for anticancer treatment compared to the photodynamic method, there are not enough related studies in the literature and this study aims to contribute to the development of sono-photodynamic studies. For this purpose, the Schiff base substituted silicon phthalocyanines were designed and synthesized as effective sensitizer candidates and the photophysicochemical and sono-photochemical features of the phthalocyanines were examined to increase singlet oxygen efficiency. The calculated Φ Δ values indicate that the contribution of substituent groups improved the production of singlet oxygen compare to silicon (IV) phthalocyanine dichloride (SiPcCI 2 ), and also the sono-photochemical applications increased the singlet oxygen yields. The Φ Δ values (Φ Δ =0.76 for axially bis-{4-[(E)-(pyridin-3-ylimino)methyl]phenol} substituted silicon (IV) phthalocyanine (2a), 0.68 for axially bis-4-[(E)-{[(pyridin-3-yl)methyl]imino}methyl]phenol substituted silicon (IV) phthalocyanine (2b) in photochemical study) reached to Φ Δ =0.98 for 2a , 0.94 for 2b in sono-photochemical study. This article will enrich the literature on increasing singlet oxygen yield.