Deep Brain Stimulation in Patients With Mutations in Parkinson's Disease-Related Genes: A Systematic Review.
Lais Machado de OliveiraEgberto Reis BarbosaCamila Catherine AquinoRenato Puppi MunhozAlfonso FasanoRubens Gisbert CuryPublished in: Movement disorders clinical practice (2019)
Subthalamic DBS results in positive outcomes in the short term in patients with Parkin, GBA, and leucine-rich repeat kinase 2 (non-R144G) mutations, although the small sample size limits the interpretation of our findings. Longer and larger cohorts of follow-up, with broader nonmotor symptom evaluations will be necessary to better customize DBS therapy in this population.