Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis.
Michael William KnitzThomas E BickettLaurel B DarraghAyman J OweidaShilpa BhatiaBenjamin Van CourtShiv BhuvaneMiles PiperJacob GadwaAdam C MuellerDiemmy NguyenVaruna NangiaDouglas G OsborneXiyuan BaiSarah E FerraraMary-Keara BossAndrew GoodspeedMatthew A BurchillBeth Ann Jiron TamburiniEdward D ChanCurtis R PickeringEric T ClambeySana D KaramPublished in: Journal for immunotherapy of cancer (2021)
Regulating Treg functionality and DC activation status within the lymph node is critical for generating a T cell effector response in these highly radioresistant tumors. These findings underscore the plasticity of Tregs and represent a new therapeutic opportunity for reprogramming the tumor microenvironment in HNSCCs resistant to conventional radioimmunotherapy approaches.