Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia.
Sophie BérardSophia MorelEmma TeasdaleNitin ShivappaJames R HébertCaroline LaverdièreDaniel SinnettEmile LevyValérie MarcilPublished in: Nutrients (2020)
There is little information about how diet influences the health of childhood acute lymphoblastic leukemia (cALL) survivors. This study explores the associations between diet quality indices, cardiometabolic health indicators and inflammatory biomarkers among cALL survivors. Participants were part of the PETALE study (n = 241, median age: 21.7 years). Adherence to 6 dietary scores and caloric intake from ultra-processed foods were calculated. Multivariate logistirac regressions, Student t-tests and Mann-Whitney tests were performed. We found that 88% of adults and 46% of children adhered poorly to the Mediterranean diet, 36.9% had poor adherence to the World Health Organisation (WHO) recommendations and 76.3% had a diet to be improved according to the HEI-2015 score. On average, ultra-processed foods accounted for 51% of total energy intake. Low HDL-C was associated with a more inflammatory diet (E-DIITM score) and higher intake of ultra-processed foods. A greater E-DII score was associated with elevated insulin resistance (HOMA-IR), and consumption of ultra-processed foods was correlated with high triglycerides. Circulating levels of TNF-α, adiponectin and IL-6 were influenced by diet quality indices, while CRP and leptin were not. In conclusion, survivors of cALL have poor adherence to dietary recommendations, adversely affecting their cardiometabolic health.
Keyphrases
- physical activity
- weight loss
- healthcare
- public health
- young adults
- health information
- insulin resistance
- acute lymphoblastic leukemia
- mental health
- high resolution
- type diabetes
- oxidative stress
- glycemic control
- adipose tissue
- health promotion
- weight gain
- bone marrow
- skeletal muscle
- social media
- acute myeloid leukemia
- human health
- childhood cancer