Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer.

Giuseppe GallettiChao ZhangAda GjyreziKyle ClevelandJiaren ZhangSarah Powell Prashant V ThakkarDoron BetelManish A ShahParaskevi Giannakakou

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our data reveal that taxane resistance is more prevalent in patients with DIF-GC, support assessment of drug-target engagement as an early read-out of taxane clinical efficacy, and encourage the investigation of kinesins and other microtubule-associated proteins as potentially targetable mediators of taxane resistance in gastric cancer.

Keyphrases

metastatic breast cancer
social media
emergency department
gene expression
mass spectrometry
clinical evaluation
gas chromatography