Role of non-coding rnas in tuberculosis and their potential for clinical applications.
Mohd Iskandar JumatMaria E SarmientoArmando AcostaKai Ling ChinPublished in: Journal of applied microbiology (2023)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of mortality due to infectious diseases, only surpassed in 2020 by COVID-19. Despite the development in diagnostics, therapeutics, and evaluation of new vaccines for TB, this infectious disease remains uncontrollable due to the emergence of multi-drug resistant (MDR) and extremely-drug resistant (XDR) TB, among other factors. The development in transcriptomics (RNomics) has enabled the study of gene expression in TB. It is considered that non-coding RNAs (ncRNAs) from host [microRNAs (miRNAs)] and Mtb [small RNAs (sRNAs)] are important elements in TB pathogenesis, immune resistance, and susceptibility. Many studies have shown the importance of host miRNAs in regulating immune response against Mtb via in vitro and in vivo mice models. The bacterial sRNAs play a major role in survival, adaptation, and virulence. Here, we review the characterization and function of host and bacteria ncRNAs in TB and their potential use in clinical applications as diagnostic, prognostic, and therapeutic biomarkers.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- infectious diseases
- multidrug resistant
- pulmonary tuberculosis
- acinetobacter baumannii
- gene expression
- immune response
- staphylococcus aureus
- pseudomonas aeruginosa
- escherichia coli
- coronavirus disease
- sars cov
- dna methylation
- small molecule
- cardiovascular events
- cystic fibrosis
- biofilm formation
- insulin resistance
- dendritic cells
- adipose tissue
- hiv infected
- case control
- antiretroviral therapy
- climate change
- drug induced
- high fat diet induced
- risk factors