Characterization of metabolic fate of phellodendrine and its potential pharmacological mechanism against diabetes mellitus by ultra-high-performance liquid chromatography-coupled time-of-flight mass spectrometry and network pharmacology.
Feng-Xiang ZhangYu-Lin-Lan YuanShuang-Shuang CuiMin LiRui-Man LiPublished in: Rapid communications in mass spectrometry : RCM (2021)
The metabolic feature of phellodendrine in vivo was revealed for the first time, and its anti-DM mechanism information for further pharmacological validations was also supplied. It also gave a direction to further elucidation of pharmacological mechanism of Cortex Phellodendri in treating DM.