Transcriptomic responses of extensively drug resistant Klebsiella pneumoniae to N-acetyl cysteine reveals suppression of major biogenesis pathways leading to bacterial killing and biofilm eradication.
Ankurita BhowmikSambuddha ChakrabortyAnusha RohitAshwini ChauhanPublished in: Journal of applied microbiology (2024)
Our results indicate that NAC kills the XDR- K. pneumoniae clinical isolates by shutting the overall metabolism and, hence, successfully eradicate in vitro biofilms formed on catheters.
Keyphrases
- drug resistant
- multidrug resistant
- klebsiella pneumoniae
- candida albicans
- acinetobacter baumannii
- transcription factor
- pseudomonas aeruginosa
- biofilm formation
- staphylococcus aureus
- single cell
- helicobacter pylori infection
- rna seq
- fluorescent probe
- living cells
- respiratory tract
- genome wide analysis
- cystic fibrosis
- escherichia coli
- helicobacter pylori