Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease.
Michael BockmayrKim HarnischLara C PohlLeonille SchweizerTheresa MohmeMeik KörnerMalik AlawiAbigail K SuwalaMario M DorostkarCamelia M MonoranuMartin HasselblattAnnika K WefersDavid CapperJürgen HenchStephan FrankTimothy E RichardsonIvy TranElisa LiuMatija SnuderlLara EngertsbergerMartin BeneschAndreas von DeimlingDenise ObrechtMartin MynarekStefan RutkowskiMarkus GlatzelJulia E NeumannUlrich SchüllerPublished in: Neuro-oncology (2022)
We unraveled the morphological and clinical heterogeneity of MPE by identifying two molecularly distinct subtypes. These subtypes significantly differed in progression-free survival and will likely need different protocols for surveillance and treatment.