Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.
Chunxiao YangZihua GongXiaochen ZhangShuai MiaoBozhi LiWei XieTao WangXun HanLiang WangZhao DongSheng-Yuan YuPublished in: The journal of headache and pain (2023)
Taken together, our data support that the NPY signaling in the MHb produces analgesic and anxiolytic effects through the Y1 receptor. These findings may provide new insights into novel therapeutic targets for the treatment of migraine.