Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study.
Helena HuergaSekai Chenai Mathabire RuckerLoide CossaMathieu BastardIsabel AmorosIvan ManhiçaKuzani MbenderaAlex TelnovElisabeth SzumilinElisabeth Sanchez-PadillaLucas MolfinoPublished in: PLoS medicine (2019)
LAM has diagnostic value for identifying TB in HIV-positive patients with signs and symptoms of TB and advanced immunodeficiency, including those with a CD4 count of 100-199 cells/μl. In this study, the use of LAM enabled the diagnosis of TB in half of the patients with confirmed TB disease; without LAM, these patients would have been missed. The rapid identification and treatment of TB enabled by LAM may decrease overall mortality risk for these patients.
Keyphrases
- hiv positive
- mycobacterium tuberculosis
- end stage renal disease
- men who have sex with men
- antiretroviral therapy
- ejection fraction
- induced apoptosis
- south africa
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- oxidative stress
- human immunodeficiency virus
- blood pressure
- cell death
- depressive symptoms
- single cell
- smoking cessation
- pi k akt