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Prophylactic antigen-specific T-cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant.

David Jonathan GottliebLeighton Edward ClancyBarbara WithersHelen Marie McGuireFabio LucianiMandeep SinghBrendan HughesBrian GlossDavid KlimanChun Kei Kris MaShyam PanickerDavid BishopMing-Celine DubosqZiduo LiSelmir AvdicKenneth MicklethwaiteEmily Blyth
Published in: Clinical & translational immunology (2021)
Rapid reconstitution of immunity to a broad range of viral and fungal infections can be achieved using a multi-pathogen-specific T-cell product. The development of GVHD after T-cell infusion suggests that infection-specific T-cell therapy after allogeneic stem cell transplant should be combined with other strategies to reduce graft-versus-host disease.
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