Prophylactic antigen-specific T-cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant.
David Jonathan GottliebLeighton Edward ClancyBarbara WithersHelen Marie McGuireFabio LucianiMandeep SinghBrendan HughesBrian GlossDavid KlimanChun Kei Kris MaShyam PanickerDavid BishopMing-Celine DubosqZiduo LiSelmir AvdicKenneth MicklethwaiteEmily BlythPublished in: Clinical & translational immunology (2021)
Rapid reconstitution of immunity to a broad range of viral and fungal infections can be achieved using a multi-pathogen-specific T-cell product. The development of GVHD after T-cell infusion suggests that infection-specific T-cell therapy after allogeneic stem cell transplant should be combined with other strategies to reduce graft-versus-host disease.
Keyphrases
- stem cells
- cell therapy
- stem cell transplantation
- bone marrow
- sars cov
- hematopoietic stem cell
- mesenchymal stem cells
- low dose
- cancer therapy
- gram negative
- candida albicans
- cell wall
- multidrug resistant
- drug delivery
- acute lymphoblastic leukemia
- allogeneic hematopoietic stem cell transplantation
- quantum dots
- loop mediated isothermal amplification
- sensitive detection