RUNX transcription factors: orchestrators of development.

Renaud MevelJulia E DraperMichael Lie-A-LingValerie Kouskoff Georges Lacaud

Published in: Development (Cambridge, England) (2019)

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

Keyphrases

transcription factor
stem cells
genome wide identification
dna binding
gene expression
high throughput
single molecule
young adults
mesenchymal stem cells
single cell
bone marrow