Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia.

Pablo Iruzubieta Marta MonzonTomás CastiellaTeresa RamírezMª Concepción Junquera

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)

Thus, primary cilia and Hedgehog signalling would be fundamental in tumoural microenvironment control of GIST cells for their maintenance, differentiation and proliferation.

Keyphrases

induced apoptosis
signaling pathway
stem cells
cell cycle arrest
oxidative stress
cell death
pi k akt