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A dual-mode probe based on AIE and TICT effects for the detection of the hypochlorite anion and its bioimaging in living cells.

Yang ZhouHai XuQing-Xiu LiZong-Rui HouYa-Wen WangYu Peng
Published in: Organic & biomolecular chemistry (2023)
Based on aggregation-induced emission (AIE) and twisted intramolecular charge transfer (TICT) mechanisms, a fluorescent probe SWJT-12 for the detection of ClO - was designed by using the CN bond as a reactive group. This synthesized probe can react with ClO - in a high aqueous phase, and it shows a large Stokes shift (144 nm) and low biological toxicity. Its limit of detection was calculated to be 0.28 μM. Furthermore, SWJT-12 was successfully used for ratiometric imaging of the exogenous hypochlorite anion in living cells.
Keyphrases
  • living cells
  • fluorescent probe
  • loop mediated isothermal amplification
  • ionic liquid
  • real time pcr
  • single molecule
  • label free
  • photodynamic therapy
  • oxide nanoparticles