The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models.
Silvia Aparecida TeixeiraMayara de Cassia LuzziAna Carolina Baptista Moreno MartinTerence Teixeira DuarteMônica de Oliveira LealGustavo Ramos TeixeiraMonise Tadin ReisCarlos Roberto Almeida JuniorKarina SantosMatias Eliseo MelendezDiego da Cunha Silveira Alves da SilvaPriscila Neves BernéculeHigor Vinicius Lourenço FirminoAna Laura Vieira AlvesDenise Peixoto GuimarãesJoão Vitor BorduquiAna Carolina LausBruna Minniti MançanoRui Manuel ReisPublished in: Veterinary sciences (2022)
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and Apc Min mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.