Visual Pathway Involvement in NMDA Receptor Encephalitis: A Clinical, Optical Coherence Tomography, and 18-Fluorodeoxyglucose PET/CT Approach.
Grigorios KalaitzidisAngeliki FilippatouNicholas FioravanteAlissa RothmanElias S SotirchosEleni VasileiouHenrik EhrhardtAgustina QuirogaNicole PellegriniOlwen C MurphyHussein MoussaDimitrios C LadakisJeffrey LambeKathryn C FitzgeraldLilja SolnesArun VenkatesanPeter A CalabresiShiv SaidhaJohn C ProbascoPublished in: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society (2022)
Although the visual system seems to be involved in anti-NMDAR encephalitis, no retinal structural or occipital cortex functional abnormalities seem to be responsible for the visual dysfunction. When detected acutely, occipital lobe hypometabolism in anti-NMDAR encephalitis does not seem to associate with subsequent retrograde trans-synaptic degenerative phenomena, potentially reflecting reversible neuronal/synaptic dysfunction in the acute phase of the illness rather than neuronal degeneration.