Comparison of the treatment efficacy of umbilical mesenchymal stem cell transplantation via renal subcapsular and parenchymal routes in AKI-CKD mice.

Mengjie HuangDuo LiJianwen ChenYuwei JiTingyu SuYulan ChenYingjie ZhangYuanda WangFei LiShang ChenYu DongQinggang LiLingling WuZhe FengJie WuLi ZhangZongjin LiGuangyan CaiXiang-Mei Chen

Published in: Stem cell research & therapy (2022)

Subcapsular MSC transplantation may be an ideal route of MSC delivery for AKI treatment, and collagen I can provide a superior microenvironment for cell-cell and cell-matrix interactions to stabilize the retention rate of MSCs in the kidney.

Keyphrases

stem cell transplantation
cell therapy
single cell
stem cells
acute kidney injury
high dose
chronic kidney disease
mesenchymal stem cells
bone marrow
metabolic syndrome
combination therapy
clinical evaluation