Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program.

This study generally confirmed our previous report regarding age-related behavioral changes from young to middle age and expanded the previous observations by examining the behaviors of old-aged mice. Our results show age-related changes in a wide range of behaviors in mice from young to old age. Most behaviors showed gradual changes with advancing age, but some types of behaviors, such as vertical activity, prepulse inhibition, and depression-related behavior, did not show unidirectional changes with age. These findings provide basic information about the behavioral characteristics of young, middle-aged, and aged male C57BL/6J mice.