ENAM mutations and digenic inheritance.

Hong ZhangYuanyuan HuFigen SeymenMine KoruyucuYelda KasimogluShih-Kai WangJohn Timothy WrightMichael W HavelChuhua ZhangJung-Wook KimJames P SimmerJan C-C Hu

Published in: Molecular genetics & genomic medicine (2019)

Novel ENAM mutations causing AI were identified, raising to 22 the number of ENAM variations known to cause AI. The severity of the enamel phenotype in Enam+/- Ambn+/- double heterozygous mice is caused by composite digenic effects. Digenic inheritance should be explored as a cause of AI in humans.

Keyphrases

artificial intelligence
mitochondrial dna
machine learning
deep learning
high fat diet induced
metabolic syndrome
adipose tissue