ALYREF Drives Cancer Cell Proliferation Through an ALYREF-MYC Positive Feedback Loop in Glioblastoma.
Jianjun WangYuchen LiBinbin XuJiao DongHaiyan ZhaoDongxia ZhaoYong WuPublished in: OncoTargets and therapy (2021)
Our data showed that ALYREF is regulated by MYC at the transcriptional level. ALYREF drives GBM cell proliferation by activating the Wnt/β-catenin signaling pathway and stabilizing MYC mRNA, suggesting that an ALYREF-MYC positive feedback loop might be a potential therapeutic target for treating GBM patients.
Keyphrases
- cell proliferation
- transcription factor
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- stem cells
- signaling pathway
- pi k akt
- peritoneal dialysis
- papillary thyroid
- gene expression
- prognostic factors
- electronic health record
- big data
- squamous cell
- patient reported
- deep learning
- young adults
- heat shock protein