Does biologic survival depend on co-prescribed methotrexate dose in established rheumatoid arthritis? A real-world study.

Our results suggest that to improve biologic retention, the MTX dose should be increased to 20 mg a week or more, and, in people with MTX intolerance, csDMARDs co-presciption can be an alternative strategy. Maintenance with a low-to-moderate MTX dose can lead to poorer retention rates.