Rapid Resolution of Recalcitrant Headache With Pasireotide in an Adult Patient With Acromegaly.
Zeinab DabbousZaina RohaniAbeer Kaled AbdalrubbYaman AlkailaniRosario PivonelloTarik ElhaddPublished in: JCEM case reports (2024)
Acromegaly is a chronic hormonal disorder caused by excessive GH secretion. In addition to physiological symptoms, it is often accompanied by debilitating headaches. Although effective treatment options exist, achieving complete symptom control and disease management can still be challenging. This case report chronicles the clinical journey of a 38-year-old male diagnosed with acromegaly in 2013. Despite prior interventions, including surgery and treatment with first-generation somatostatin analogues, severe frequent headaches persisted. Following a switch to pasireotide, the patient reported rapid and complete resolution of headaches and normalization of IGF-1 levels within a month of the treatment switch. This report underscores the challenges in acromegaly management and confirms the potential utility of pasireotide for patients suffering from treatment-resistant headache.
Keyphrases
- patient reported
- growth hormone
- case report
- end stage renal disease
- minimally invasive
- ejection fraction
- newly diagnosed
- physical activity
- early onset
- single molecule
- metabolic syndrome
- coronary artery bypass
- body mass index
- molecular docking
- cell proliferation
- atrial fibrillation
- depressive symptoms
- skeletal muscle
- risk assessment
- combination therapy
- binding protein
- prognostic factors
- insulin resistance
- replacement therapy
- signaling pathway
- climate change
- surgical site infection
- loop mediated isothermal amplification
- patient reported outcomes
- molecular dynamics simulations