Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model.
Amandeep MahalNichole Young-LinAmy DobberfuhlJaclyn EstesCraig Vance ComiterPublished in: Investigative and clinical urology (2018)
Pioglitazone, a PPAR-γ agonist, improved bladder function in cyclophosphamide-induced cystitis by both observed urinary frequency and measured cystometric capacity. Urothelial structural integrity was also improved. Pioglitazone, due to a propensity to cause bladder mucosal proliferation, may prove useful for treating IC, and deserves further investigation.