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Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model.

Amandeep MahalNichole Young-LinAmy DobberfuhlJaclyn EstesCraig Vance Comiter
Published in: Investigative and clinical urology (2018)
Pioglitazone, a PPAR-γ agonist, improved bladder function in cyclophosphamide-induced cystitis by both observed urinary frequency and measured cystometric capacity. Urothelial structural integrity was also improved. Pioglitazone, due to a propensity to cause bladder mucosal proliferation, may prove useful for treating IC, and deserves further investigation.
Keyphrases
  • urinary tract
  • spinal cord injury
  • high glucose
  • low dose
  • signaling pathway
  • high dose
  • diabetic rats
  • high grade
  • type diabetes
  • endothelial cells
  • drug induced
  • replacement therapy
  • binding protein