Activation of Notch1-GATA3 pathway in asthma bronchial epithelial cells induced by acute PM2.5 exposure and the potential protective role of microRNA-139-5p.
Junjun HuangYan HuYunxia WangZhou JinPublished in: The Journal of asthma : official journal of the Association for the Care of Asthma (2024)
Acute PM2.5 exposure can activate Notch1-GATA3 pathway in asthma bronchial epithelial cells model, which might be involved in PM2.5-induced asthma exacerbation. miR-139-5p has a potential protective role of inhibiting PM2.5-induced asthma airway inflammation by targeting Notch1.
Keyphrases
- chronic obstructive pulmonary disease
- air pollution
- lung function
- particulate matter
- drug induced
- polycyclic aromatic hydrocarbons
- allergic rhinitis
- liver failure
- heavy metals
- respiratory failure
- cell proliferation
- high glucose
- water soluble
- transcription factor
- diabetic rats
- signaling pathway
- cystic fibrosis
- aortic dissection
- oxidative stress
- intensive care unit
- human health
- mechanical ventilation