Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells.

Karthik SambathTinghan ZhaoZhaoxiong Wan Yuanwei Zhang

Published in: Chemical communications (Cambridge, England) (2019)

A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
dna methylation
electron transfer
living cells
signaling pathway
fluorescent probe
cell death
wastewater treatment
minimally invasive
cell cycle arrest
aqueous solution