Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius.

Nhan Trung Nguyen Phu Hoang Dang Hai Xuan Nguyen Truong Nhat Van Do Tho Huu Le Tuyen Q H Le Mai Thanh Thi Nguyen

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of Streblus ilicifolius (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC50 value of 0.01 μM. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. The analysis of the docked poses confirmed that 1 showed better binding affinity for oxy-tyrosinase than that of 2.

Keyphrases

high resolution
magnetic resonance
molecular docking
molecular dynamics
electronic health record
protein protein
machine learning
big data
transcription factor
data analysis
capillary electrophoresis