The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium.

Yidan RenYi ZhangLixia FanQinlian JiaoYunshan WangQin Wang

Published in: Respiratory research (2019)

Our results showed that CUL4A was overexpressed in lung epithelium of COPD patients, and CUL4A could regulate EMT of human small airway epithelium, which revealed a new mechanism of remodeling of small airway epithelium of COPD patients.

Keyphrases

epithelial mesenchymal transition
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
chronic obstructive pulmonary disease
peritoneal dialysis
endothelial cells
transcription factor
transforming growth factor
patient reported outcomes
single cell