A detailed methodology for a three-dimensional, self-structuring bone model that supports the differentiation of osteoblasts towards osteocytes and the production of a complex collagen-rich mineralised matrix.

Melissa FinlayLaurence A HillGeorgiana NeagBinal PatelMiruna ChiparaHannah C LamontKathryn FrostKieran PatrickJonathan W LewisThomas NicholsonJames EdwardsSimon W JonesLiam M GroverAmy J Naylor

Published in: F1000Research (2024)

bone models that are responsive to exogenous stimuli, offering a versatile platform for conducting preclinical translatable research studies.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women
high throughput
cell therapy
bone marrow
single cell