What Do Reactive Fragments Actually Do in Cells?

Published in: Angewandte Chemie (International ed. in English) (2016)

Covalently binding molecules are frequently regarded as being generally promiscuous. In a recent study, binding selectivities and cellular target proteins of a wide variety of reactive fragments are examined in a proteome-wide context.

Keyphrases

induced apoptosis
cell cycle arrest
dna binding
binding protein
signaling pathway
cell proliferation